Functions of RNA-Binding Proteins in Cardiovascular Disease.
Grégoire RuffenachLejla MedzikovicWasila SunJason HongMansoureh EghbaliPublished in: Cells (2023)
Gene expression is under tight regulation from the chromatin structure that regulates gene accessibility by the transcription machinery to protein degradation. At the transcript level, this regulation falls on RNA-binding proteins (RBPs). RBPs are a large and diverse class of proteins involved in all aspects of a transcript's lifecycle: splicing and maturation, localization, stability, and translation. In the past few years, our understanding of the role of RBPs in cardiovascular diseases has expanded. Here, we discuss the general structure and function of RBPs and the latest discoveries of their role in pulmonary and systemic cardiovascular diseases.
Keyphrases
- cardiovascular disease
- gene expression
- genome wide
- transcription factor
- dna methylation
- rna seq
- cardiovascular risk factors
- cardiovascular events
- type diabetes
- pulmonary hypertension
- blood brain barrier
- copy number
- nucleic acid
- binding protein
- metabolic syndrome
- protein protein
- coronary artery disease
- genome wide identification
- small molecule