Subcellular Distribution of Thyroid Hormone Receptor Beta in Ovarian Cancer.

Sabine HeubleinUdo JeschkeCornelia SattlerChristina KuhnAnna HesterBastian Czogalla Fabian TrillschSven MahnerDoris MayrElisa SchmoeckelNina Ditsch

Published in: International journal of molecular sciences (2022)

Cytoplasmatic localization of TR beta was associated with reduced OS, at least in univariate analysis. Since TRs have long been supposed to mainly function via the regulation of gene transcription in the nucleus, cytoplasmatic shifting might be interpreted as a regulator of their activity.

Keyphrases

transcription factor
genome wide
copy number
gene expression
genome wide identification