Blockade of thromboxane A2 signaling attenuates ethanol-induced myocardial inflammatory response in mice.
Weilun AiCarol A CaseyParas Kumar MishraYazen AlnoutiSohel DariaViswanathan SaraswathiPublished in: Alcohol, clinical & experimental research (2024)
This study demonstrates that ethanol promotes the NLRP3 signaling pathway within the myocardium, leading to a pro-inflammatory milieu that potentially initiates early myocardial remodeling, and TP-R antagonism attenuates this effect.
Keyphrases
- inflammatory response
- signaling pathway
- left ventricular
- high glucose
- lipopolysaccharide induced
- diabetic rats
- pi k akt
- high fat diet induced
- epithelial mesenchymal transition
- heart failure
- type diabetes
- oxidative stress
- immune response
- metabolic syndrome
- endothelial cells
- cell proliferation
- nlrp inflammasome
- atrial fibrillation
- wild type