Daptomycin Pharmacokinetics and Pharmacodynamics in Patients on Methadone Substitution Therapy.
Simona De GregoriAnnalisa De SilvestriMaria Delfina MolinaroVincenzina MonzilloSimona BiscariniMarta ColaneriIlaria GallazziAntonella BartoliRaffaele BrunoElena M SeminariPublished in: European journal of drug metabolism and pharmacokinetics (2021)
Treatment of Staphylococcus aureus IE in IDUs on methadone treatment requires the use of high daptomycin daily doses in order to achieve satisfactory pharmacodynamic parameters. Close monitoring of the daptomycin plasma concentration is suggested.