Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.
Rana J T Al-BaghdadiInna A NikonorovaEmily T MirekYongping WangJinhee ParkWilliam J BeldenRonald C WekTracy G AnthonyPublished in: Scientific reports (2017)
GCN2 and ATF4 serve complementary roles in the hepatic response to asparaginase. GCN2 functions to limit inflammation and mTORC1 signaling whereas ATF4 serves to limit the amino acid response and prevent ER stress during amino acid depletion by asparaginase.