Peripheral blood DNA methylation signatures and response to tofacitinib in moderate-to-severe ulcerative colitis.

Vincent JoustraAndrew Y F Li YimSara van GennepIshtu HagemanT de WaardEvgeni LevinPeter LaufferWouter J de JongePeter HennemanMark LöwenbergGeert R D'Haens

Published in: Journal of Crohn's & colitis (2023)

Our observations demonstrate the utility of genome-wide PB DNA methylation signatures to predict response to tofacitinib.

Keyphrases

genome wide
ulcerative colitis
dna methylation
peripheral blood
gene expression
copy number
rheumatoid arthritis
heavy metals
high intensity
early onset
risk assessment