Activation of trace amine-associated receptor 1 selectively attenuates the reinforcing effects of morphine.

Jianfeng LiuRobert SeamanBernard N JohnsonRuyan WuJimmy VuJingwei TianYanan ZhangJun-Xu Li

Published in: British journal of pharmacology (2021)

These results indicated that TA1 receptor activation selectively attenuated the reinforcing, but not withdrawal or antinociceptive effects of morphine, suggesting that selective TA1 receptor agonists might be useful to combat opioid addiction, while sparing the analgesic effects.

Keyphrases

chronic pain
anti inflammatory
pain management
robot assisted
neuropathic pain
binding protein