Combined effect of modifiable and non-modifiable risk factors for colorectal cancer risk in a pooled analysis of 11 population-based studies.
Xiaoliang WangKelli O'ConnellJihyoun JeonMingyang SongDavid HunterMichael HoffmeisterYi LinSonja BerndtHermann BrennerAndrew T ChanJenny Chang-ClaudeJian GongMarc J GunterTabitha A HarrisonRichard B HayesAmit JoshiPolly NewcombRobert SchoenMartha L SlatteryAshley VargasJohn D PotterLoic Le MarchandEdward GiovannucciEmily WhiteLi HsuUlrike PetersMengmeng DuPublished in: BMJ open gastroenterology (2019)
Changes in modifiable risk factors may result in a substantial decline in CRC risk in both sexes. Those with high inherited risk may reap greater benefit from lifestyle modifications. Our results suggested comprehensive evaluation of environmental factors may facilitate CRC risk stratification.