Pentacyclic triterpenes from the leaves of Camellia hakodae Ninh.

Nine pentacyclic triterpene derivatives including new 3- O-cis-p- coumaroyl trichadenic acid B ( 1 ) and two new ursane-type triterpene derivatives, 11 α ,12-[1-(methyl)-2-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3 β -ol ( 2 ) and 11 α ,12-[2-(methyl)-1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-dioxy]-urs-12-ene-3 β -ol ( 3 ) were isolated from the leaves of Camellia hakodae Ninh., along with six known compounds ( 4-9 ). This is the first report on pentacyclic triterpenoids from this species. New compounds 1 - 3 and compound 7 were tested for cytotoxic activity against four human cancer cell lines (KB; Hep-G2; Lu; MCF-7) using the MTT assay to show moderate activity.