Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor.
Zhiyu DaiMaggie M ZhuYi PengNarsa MachireddyColin E EvansRoberto MachadoXianming ZhangYou-Yang ZhaoPublished in: American journal of respiratory and critical care medicine (2019)
These findings demonstrate that pharmacological inhibition of HIF-2α is a promising novel therapeutic strategy for the treatment of severe vascular remodeling and right heart failure in patients with PAH.