Potential role of TP63 in apical periodontitis development.

Letícia Chaves de SouzaB M CrozetaL GuajardoF H Brasil da CostaManoel Damião de Sousa-NetoA LetraR M Silva

Published in: International endodontic journal (2019)

Apical periodontitis is a complex multifactorial condition and it is likely that multiple genes and environmental effects may influence its susceptibility, progression or both. TP63 variants may play a role in AP pathogenesis and susceptibility, individually or interactively with other genes. Additional studies in other populations and functional studies are needed to improve understanding of the role of TP63 in AP.

Keyphrases

transcription factor
genome wide
case control
genome wide identification
bioinformatics analysis
copy number
genome wide analysis
gene expression
human health
risk assessment