Endothelial Cell-Specific Prolyl Hydroxylase-2 Deficiency Augments Angiotensin II-Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice.
Bo LiuHeng ZengHan SuQuinesha A WilliamsJessie BesansonYingjie ChenJian-Xiong ChenPublished in: Journal of the American Heart Association (2024)
Knockout of endothelial PHD2 enhanced angiotensin II-induced cardiac fibrosis by mechanisms involving increasing arterial stiffness and pericyte-myofibroblast cell transitions.
Keyphrases
- angiotensin ii
- high glucose
- angiotensin converting enzyme
- vascular smooth muscle cells
- endothelial cells
- diabetic rats
- blood brain barrier
- blood pressure
- left ventricular
- drug induced
- single cell
- oxidative stress
- cell therapy
- type diabetes
- transforming growth factor
- heart failure
- metabolic syndrome
- insulin resistance
- mesenchymal stem cells
- skeletal muscle
- signaling pathway
- bone marrow
- vascular endothelial growth factor
- liver fibrosis