High mechanical conditioning by tumor extracellular matrix stiffness is a predictive biomarker for anti-fibrotic therapy in HER2-negative breast cancer.
Miguel Quintela-FandinoBegoña BermejoEsther Zamora AdelantadoFernando Moreno AntónJosé Angel García-SaenzSonia PernasNoelia Martínez JáñezDesirée JiménezEncarna AdroverR Andrés ConejeroSilvana MourónMaria Jose BuenoLuis Manso SanchezGemma ViñasEmilio AlbaAntonio LlombartJavier CortesCristina TebarDenise J RoeAdam GrantAdam W WatsonRamón ColomerGhassan MouneimnePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
High MeCo is predictive of poor outcomes in HER2-negative early breast cancer, although this risk can be mitigated by nintedanib, which is able to specifically reduce mechanical conditioning.