Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution.
Giovanni De MarcoA LomartireA CalvoA RissoE De LucaM MostertJ MandrioliC CaponnettoG BorgheroU ManeraA CanosaC MogliaG RestagnoN FiniC TarellaM T GiordanaM T RinaudoA ChiòPublished in: Neuropathology and applied neurobiology (2016)
In ALS forms characterized by TDP-43 mislocalization in motor neurons, monocytes display this alteration, even when not manifest in CLM. Monocytes may be used to support diagnosis, as well as to identify subjects at risk, of ALS and to develop/monitor targeted treatments.