Dimericbiscognienyne A: A Meroterpenoid Dimer from Biscogniauxia sp. with New Skeleton and Its Activity.
Huan ZhaoGuo-Dong ChenJian ZouRong-Rong HeSheng-Ying QinDan HuGuo-Qiang LiLiang-Dong GuoXin-Sheng YaoHao GaoPublished in: Organic letters (2016)
Dimericbiscognienyne A (1), an unusual diisoprenyl-cyclohexene-type meroterpenoid dimer, was isolated from Biscogniauxia sp. together with three new monomeric diisoprenyl-cyclohexene-type meroterpenoids (2-4) and one new isoprenyl-benzoic acid-type meroterpenoid (5). All structures were determined by extensive NMR spectroscopic methods, quantum chemical calculations, chemical derivatization, and X-ray crystallography. The formation of 1 is related to a unique intermolecular redox coupling Diels-Alder adduct reaction. Their cytotoxicities and short-term memory enhancement activities against Alzheimer's disease were assessed.
Keyphrases
- high resolution
- molecular dynamics
- magnetic resonance
- ms ms
- density functional theory
- working memory
- high performance liquid chromatography
- molecular dynamics simulations
- mass spectrometry
- liquid chromatography tandem mass spectrometry
- gas chromatography mass spectrometry
- liquid chromatography
- simultaneous determination
- solid state
- tandem mass spectrometry
- high resolution mass spectrometry