Clustering of cortical dynein regulates the mechanics of spindle orientation in human mitotic cells.

Maya I Anjur-DietrichVicente Gomez HererraReza FarhadifarHaiyin WuHolly MertaShirin BahmanyarMichael J ShelleyDaniel J Needleman

Published in: bioRxiv : the preprint server for biology (2023)

Cytoplasmic viscosity does not determine the spindle's resistance to rotationEach astral microtubule that contacts the cell cortex is pulled on by a single dynein motorPulling forces on astral microtubules determine the mechanics of spindle orientationThe mechanics of spindle orientation is regulated by clustering of dynein motors at the cell cortex.

Keyphrases

single cell
rna seq
induced apoptosis
endothelial cells
functional connectivity
stem cells
signaling pathway
bone marrow
pi k akt