Towards detection of brain injury using multimodal non-invasive neuromonitoring in adults undergoing extracorporeal membrane oxygenation.
Irfaan A DarImad R KhanRoss K MaddoxOlga SelioutskiKelly L DonohueMark A MarinescuSunil M PrasadNadim H QuaziJack S DonlonEmily A LooseGabriel A RamirezJingxuan RenJoseph B MajeskiKenneth AbramsonTurgut DurduranDavid R BuschRegine ChoePublished in: Biomedical optics express (2020)
Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary bypass that provides life-saving support to critically ill patients whose illness is progressing despite maximal conventional support. Use in adults is expanding, however neurological injuries are common. Currently, the existing brain imaging tools are a snapshot in time and require high-risk patient transport. Here we assess the feasibility of measuring diffuse correlation spectroscopy, transcranial Doppler ultrasound, electroencephalography, and auditory brainstem responses at the bedside, and developing a cerebral autoregulation metric. We report preliminary results from two patients, demonstrating feasibility and laying the foundation for future studies monitoring neurological health during ECMO.
Keyphrases
- extracorporeal membrane oxygenation
- brain injury
- acute respiratory distress syndrome
- cerebral ischemia
- subarachnoid hemorrhage
- respiratory failure
- end stage renal disease
- high resolution
- newly diagnosed
- healthcare
- public health
- ejection fraction
- chronic kidney disease
- cerebral blood flow
- mental health
- resistance training
- heart rate
- patient reported outcomes
- intensive care unit
- health information
- current status
- climate change
- low grade
- heat stress
- risk assessment
- chronic pain
- mass spectrometry
- blood flow
- hearing loss
- loop mediated isothermal amplification
- functional connectivity