Oxidative Stress in Kidney Diseases: The Cause or the Consequence?
Natalia KrataRadosław ZagożdżonBartosz ForoncewiczKrzysztof MuchaPublished in: Archivum immunologiae et therapiae experimentalis (2017)
Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism's cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In nephrology, researchers are looking for alternative methods replacing the renal biopsy in patients with suspicion of chronic kidney disease (CKD). Currently, CKD is a frequent health problem in world population, which can lead to progressive loss of kidney function and eventually to end-stage renal disease. The course of CKD depends on the primary disease. It is assumed that one of the factors influencing the course of CKD might be OS. In the current work, we review whether monitoring the OS-associated biomarkers in nephrology patients can support the decision-making process regarding diagnosis, prognostication and treatment initiation.
Keyphrases
- chronic kidney disease
- end stage renal disease
- oxidative stress
- induced apoptosis
- decision making
- public health
- healthcare
- dna damage
- gene expression
- multiple sclerosis
- ischemia reperfusion injury
- peritoneal dialysis
- mental health
- cell cycle arrest
- signaling pathway
- cell death
- ultrasound guided
- weight gain
- human health
- fine needle aspiration
- newly diagnosed
- health promotion
- heat stress
- replacement therapy
- weight loss