Regulation of Chirality in Metal-Organic Frameworks (MOFs) Based on Achiral Precursors through Substituent Modification.

The generation and regulation of chirality are closely related to the origin of life. Using achiral precursors to spontaneously build chiral MOFs remains a major challenge. Here, a method to synthesize chiral MOFs from achiral precursors by utilizing chiral fragments was achieved. The transformation from chiral fragments of 1 to chiral frameworks of 2 and 3 was realized by modifying the substituents, and the enantiomer resolution of 3 - P 4 1 2 1 2 and 3 - P 4 3 2 1 2 was achieved by d/l camphoric acid. 3 was then further studied in applications.