Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only.
Lucile GrimbertMaria-Nieves SanzMélanie GressetteCatherine Rucker-MartinMarta NovotovaAudrey SolgadiAhmed KarouiSusana GomezKaveen BedouetEric JacquetChristophe LemaireVladimir VekslerMathias MericskayRenée Ventura-ClapierJerome PiquereauAnne GarnierPublished in: Biology of sex differences (2021)
Our results confirm the close link between AMPK and cardiac mitochondrial function, but also highlight links with cardiac fibrosis. Importantly, we show that AMPK is differently involved in these processes in males and females, which may have clinical implications for the use of AMPK activators in the treatment of heart failure.