The phase changes of M1/M2 phenotype of microglia/macrophage following oxygen-induced retinopathy in mice.

Jia LiShanshan YuXi LuKaixuan CuiXiaoyu TangYue XuXiaoling Liang

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)

Microglia/macrophage participate actively in the natural process of OIR in mice, and two phenotypes exert different functions. Treatment modulating microglia/macrophage polarize toward M2 phenotype might be a novel and promising method for ocular neovascular diseases such as retinopathy of prematurity (ROP), wet age-related macular degeneration (wAMD), and diabetic retinopathy (DR).

Keyphrases

age related macular degeneration
diabetic retinopathy
inflammatory response
adipose tissue
neuropathic pain
high fat diet induced
optical coherence tomography
diabetic rats
high glucose
insulin resistance
stress induced
smoking cessation