Two new 30-norfriedelane triterpenes from Caloncoba glauca (P. Beauv.) Gilg (Achariaceae).
Charlemagne Ndoumbe TambaWillifred Dongmo Tekapi TsopgniBernard Samuel Hodjie FotsoJean Pierre Longue EkonMohamed Foundikou NsangouJudith Caroline Ngo NyobeNorbert SewaldJean Claude NdomPublished in: Natural product research (2023)
The chemical investigation of the methanolic root extract of Caloncoba glauca (P. Beauv.) Gilg exhibited two new 30-norfriedelane triterpenes, glaucalactones A and B ( 1-2 ), together with eight known compounds, caloncobalactone ( 3 ), friedelin ( 4 ), friedelanol (5 ), 3-oxo-friedelan-28-oic acid ( 6 ), stigmasterol ( 7 ), β -sitosterol ( 8 ), β -sitosterol-3- O - β -D-glucopyranoside ( 9 ) and pentacosanoic acid ( 10 ). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities. Compound 1 displayed weak antibacterial effect with MIC value of 125 μg/mL against Staphylococcus aureus and Escherishia coli . Compound 6 exhibited moderated antifungal activity against Candida krusei with MIC value of 62.5 μg/mL. All the isolates were found to be inactive as antioxidants in the DPPH, ABTS and FRAP assays.
Keyphrases
- anti inflammatory
- staphylococcus aureus
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- candida albicans
- oxidative stress
- high resolution
- biofilm formation
- silver nanoparticles
- magnetic resonance
- escherichia coli
- genetic diversity
- multiple sclerosis
- molecular docking
- electronic health record
- high throughput
- high performance liquid chromatography
- wound healing
- pseudomonas aeruginosa
- deep learning
- molecular dynamics simulations
- clinical evaluation