Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke.
Gulrana KhuwajaSivakumar Sivagurunathan MoniMohammad Firoz AlamHafiz A MakeenSarvat ZafarMohammad AshafaqHassan Ahmad AlhazmiAsim NajmiShabihul Fatma SayedSyed Mohammad Shakeel IqubalPublished in: Nanomedicine (London, England) (2024)
Aim: The study was designed to develop and analyze curcumin nanoparticles. Methods: Curcumin nanoparticles were formulated and evaluated. Their efficacy in protecting against brain damage was investigated in a rat model of ischemic stroke, considering motor function, muscle strength and antioxidant enzyme activity. Results: Curcumin nanoparticles displayed a zeta potential of -55 ± 13.5 mV and an average particle size of 51.40 ± 21.70 nm. In ischemic stroke rat models, curcumin nanoparticle treatment significantly improved motor functions, and muscle strength and increased the activities of antioxidant enzymes like glutathione peroxidase, glutathione, glutathione S-transferase, superoxide dismutase and catalase, reducing oxidative stress and inflammation. Conclusion: Curcumin nanoparticles showed significant neuroprotective effects in ischemic stroke models.
Keyphrases
- oxidative stress
- diabetic rats
- atrial fibrillation
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- photodynamic therapy
- risk assessment
- high resolution
- hydrogen peroxide
- heat shock
- mass spectrometry
- climate change
- signaling pathway
- single molecule
- blood brain barrier
- brain injury
- subarachnoid hemorrhage
- combination therapy
- heat shock protein