Impact of time to start of tranexamic acid treatment on rebleed risk and outcome in aneurysmal subarachnoid hemorrhage.
Menno Robbert GermansMaud A TjerkstraRené PostAmy BrennerMervyn D I VergouwenGabriël Je RinkelYvo B W E M RoosRené van den BergBert A CoertWilliam Peter VandertopDagmar Verbaannull nullPublished in: European stroke journal (2024)
This study suggests that the effect of TXA on rebleeding is modified by time to treatment, providing a protective, albeit clinically non-relevant, effect only when started after 6 h. No difference in functional outcome was seen. Routine TXA treatment in the aneurysmal SAH population, even within a specified time frame, is not recommended to improve functional outcome.
Keyphrases