Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain.
Kai ZhangHaiping WangMei XuJacqueline A FrankJia LuoPublished in: Journal of neuroinflammation (2018)
MCP-1/CCR2 signaling played an important role in ethanol-induced microglial activation/neuroinflammation and neurodegeneration in the developing brain. The effects may be mediated by the interaction among MCP-1/CCR2 signaling, TLR4, and GSK3β.
Keyphrases
- lipopolysaccharide induced
- cerebral ischemia
- high glucose
- lps induced
- dendritic cells
- inflammatory response
- regulatory t cells
- diabetic rats
- white matter
- resting state
- drug induced
- toll like receptor
- cognitive impairment
- immune response
- signaling pathway
- functional connectivity
- endothelial cells
- multiple sclerosis
- subarachnoid hemorrhage
- cell proliferation
- blood brain barrier
- brain injury
- pi k akt
- spinal cord