Balloon cells promote immune system activation in focal cortical dysplasia type 2b.

Till S Zimmer Diede W M BroekaartMark LuinenburgCaroline MijnsbergenJasper J AninkNam Suk SimIliana MichailidouFloor E JansenPeter C van RijenJeong Ho LeeLiesbeth FrançoisJonathan van EyllStefanie DedeurwaerdereErwin Alexander van Vliet Angelika MühlebnerJames D MillsEleonora M A Aronica

Published in: Neuropathology and applied neurobiology (2021)

We conclude that, next to mutation-driven mTOR activation and seizure activity, BCs are crucial drivers of inflammation in FCD 2b. Our findings indicate that therapies targeting inflammation may be beneficial in FCD 2b.

Keyphrases

oxidative stress
induced apoptosis
cell cycle arrest
cell proliferation
cancer therapy
cell death
temporal lobe epilepsy