CHIPing away at proteomics to find correlations with myeloid neoplasms.
Avni M BhalgatJustin TaylorPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Plasma proteomic profiling to identify associations with myeloid neoplasm (MN) risk, highlights the potential of integrating protein and genetic biomarkers for detection individuals at high-risk of developing MN. These proteins also offer valuable insights into biological pathways and inflammatory mechanisms involved in the progression of clonal hematopoiesis (CH) to MN.
Keyphrases
- room temperature
- label free
- bone marrow
- dendritic cells
- transition metal
- acute myeloid leukemia
- metal organic framework
- oxidative stress
- mass spectrometry
- genome wide
- low grade
- single cell
- ionic liquid
- protein protein
- amino acid
- loop mediated isothermal amplification
- immune response
- binding protein
- gene expression
- human health
- real time pcr
- small molecule
- hematopoietic stem cell