Endotheliitis and cytokine storm as a mechanism of clot formation in COVID-19 ischemic stroke patients: A histopathologic study of retrieved clots.

Waleed BrinjikjiDavid F KallmesRenu VirmaniSimon F de MeyerAlbert J YooWilliam HumphriesOsama O ZaidatMohamed S TelebJesse George Atherton JonesAdnan H SiddiquiTommy AnderssonRaul G NogueiraSara Molina GilAndrew DouglasRosanna RossiAlexander RentzosErik CederJeanette CarlqvistDennis DunkerKatarina JoodTurgut TatlisumakKaren M Doyle

Published in: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences (2023)

Our study found higher concentrations of CRP and vWF in retrieved clots of COVID-19-positive stroke patients compared to COVID-19-negative controls. These findings support the potential role of systemic inflammation as indicated by elevated CRP and endothelial injury as indicated by elevated vWF as precipitating factors in thrombus development in these patients.

Keyphrases

coronavirus disease
sars cov
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
respiratory syndrome coronavirus
risk assessment
brain injury