The Emerging Role of Toll-Like Receptor-Mediated Neuroinflammatory Signals in Psychiatric Disorders and Acquired Epilepsy.
Anubha ChaudharyParul MehraAnand K KeshriSuraj S RawatAmit MishraAmit PrasadPublished in: Molecular neurobiology (2023)
The new and evolving paradigms of psychiatric disorders pathogenesis are deeply inclined toward chronic inflammation that leads to disturbances in the neuronal networks of patients. A strong association has been established between the inflammation and neurobiology of depression which is mediated by different toll-like receptors (TLRs). TLRs and associated signalling pathways are identified as key immune regulators to stress and infections in neurobiology. They are a special class of transmembrane proteins, which are one of the broadly studied members of the Pattern Recognition Patterns family. This review focuses on summarizing the important findings on the role of TLRs associated with psychotic disorders and acquired epilepsy. This review also shows the promising potential of TLRs in immune response mediated through antidepressant therapies and TLRs polymorphism associated with various psychotic disorders. Moreover, this also sheds light on future directions to further target TLRs as a therapeutic approach for psychiatric disorders.
Keyphrases
- toll like receptor
- immune response
- oxidative stress
- bipolar disorder
- end stage renal disease
- inflammatory response
- nuclear factor
- newly diagnosed
- major depressive disorder
- ejection fraction
- depressive symptoms
- prognostic factors
- chronic kidney disease
- peritoneal dialysis
- transcription factor
- dendritic cells
- current status
- climate change
- brain injury
- drug induced