Age-dependent variation of female preponderance across different phenotypes of multiple sclerosis: A retrospective cross-sectional study.

Andrei MicleaSalmen AnkeGreta ZoehnerLara DiemChristian P KammPanos Chaloulos-IakovidisMarius MicleaMyriam BrinerKostas KilidireasLeonidas StefanisAndrew ChanMaria Eleftheria EvangelopoulosRobert Hoepner

Published in: CNS neuroscience & therapeutics (2018)

Our data demonstrate an age dependency of female preponderance in MS except for PPMS. This could be influenced by the lifecycle of sex hormone secretion in women. In PPMS, a male preponderance was observed in all age-groups, which might point to pathophysiological mechanisms being less influenced by sex hormones.

Keyphrases

multiple sclerosis
polycystic ovary syndrome
mass spectrometry
ms ms
white matter
pregnancy outcomes
pregnant women
adipose tissue
insulin resistance
cervical cancer screening