Login / Signup

Downregulation of gene expression in hypoxic cancer cells by an activatable G-quadruplex stabiliser.

Busra UyarNezahat Gokce OzsamurFatma Secer CelikIlkyaz OzbayramSundus Erbas-Cakmak
Published in: Chemical communications (Cambridge, England) (2023)
In the research, the modulation of gene expression with a novel G-quadruplex stabiliser was analysed. Activation by the removal of bulky hypoxia-responsive substituent enhances G-quadruplex stabilisation. Hypoxic MCF7 cells incubated with the stabiliser displayed significant downregulation of oncogenes c-myc, bcl-2, and hif-1α. This study presents the first hypoxia-activatable G-quadruplex stabilization and transcriptional regulation.
Keyphrases
  • gene expression
  • dna methylation
  • endothelial cells
  • induced apoptosis
  • cell proliferation
  • signaling pathway
  • cell cycle arrest
  • oxidative stress
  • photodynamic therapy
  • drug delivery