Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway.

Li-Juan DuBing Pang Yu-Meng Tan Ya-Nan Yang Mei-Zhen ZhangQing PangMin Sun Qing Ni

Published in: Journal of diabetes research (2020)

BXXD protected MIN6 cells against t-BHP-induced apoptosis and improved insulin secretory function through modulation of the PI3K/AKT pathway and the downstream FOXO1, thus suggesting a novel therapeutic approach for type 2 diabetes mellitus (T2DM).

Keyphrases

induced apoptosis
signaling pathway
pi k akt
endoplasmic reticulum stress
oxidative stress
epithelial mesenchymal transition
type diabetes
glycemic control
cell cycle arrest
transcription factor
adipose tissue
metabolic syndrome
cell proliferation