Pd(II)-Catalyzed atroposelective C-H olefination: synthesis of enantioenriched N -aryl peptoid atropisomers.

Herein, we reported the synthesis of enantioenriched N -aryl peptoid atropisomers via Pd(II)-catalyzed atroposelective C-H olefination using the easily accessible L-pyroglutamic acid (L- p Glu-OH) as the chiral ligand. A series of optically active N -aryl peptoid atropisomers were obtained in synthetically useful yields with high enantioselectivities.