Is High-Dose Tranexamic Safe in Spine Surgery? A Systematic Review and Meta-Analysis.

Izzet Akosman Francis C LovecchioMitchell FourmanManuel SarmientoKeith LyonsStavros MemtsoudisPhilip J York

Published in: Global spine journal (2023)

Compared to LD TXA or placebo, there is moderate evidence that HD is not associated with an increased risk of medical complications. Compared to LD, there is moderate evidence that HD reduces transfusion requirements. High-Dose TXA can be safely utilized in healthy patients undergoing major spine surgery.

Keyphrases

high dose
patients undergoing
low dose
stem cell transplantation
high intensity
healthcare
cardiac surgery
risk factors
double blind
open label