GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma.

Zhaowei WangLei HeWeina LiChuanyang XuJieyu ZhangDesheng WangKefeng DouRan ZhuangBoquan JinWei ZhangQiang HaoKuo ZhangWangqian ZhangShuning WangYuan GaoJintao GuLei ShangZhijun TanHaichuan SuYingqi ZhangCun ZhangMeng Li

Published in: Journal for immunotherapy of cancer (2022)

Our results reveal the generation and function enhancement of Treg cells induced by GDF15 is a new mechanism for HCC-related immunosuppression. CD48 is the first discovered receptor of GDF15 in the immune system which provide the possibility to solve the molecular mechanism of the immunomodulatory function of GDF15. The therapeutic GDF15 blockade achieves HCC clearance without obvious adverse events.

Keyphrases

regulatory t cells
induced apoptosis
dendritic cells
nk cells
dna methylation
cell proliferation