Intraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowth.
Stefanie UhligAnne WuhrerSebastian BerlitBenjamin TuschyMarc SütterlinKaren BiebackPublished in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2020)
After breast-conserving surgery, approximately 90% of local recurrences emerge in close proximity to the initial tumor bed, potentially reflecting a significant contribution of the tumor bed to relapse. Our data show that IORT, besides the proven effect on breast cancer cells, efficiently modifies the tumor environment by having an impact on tumor bed bASC. This effect on tumor bed stromal cells might contribute to reduce the risk of tumor relapse and metastases.
Keyphrases
- minimally invasive
- adipose tissue
- type diabetes
- bone marrow
- early stage
- coronary artery disease
- radiation therapy
- machine learning
- metabolic syndrome
- mesenchymal stem cells
- lymph node
- insulin resistance
- acute coronary syndrome
- cell therapy
- big data
- percutaneous coronary intervention
- artificial intelligence
- coronary artery bypass