Adipose-Tumor Crosstalk contributes to CXCL5 Mediated Immune Evasion in PDAC.

R McKinnon WalshJoseph AmbroseJarrid L JackAustin E EadesBailey ByeMariana T RuckertAppolinaire A OlouFanuel MessaggioPrabhakar ChaliseDong PeiMichael N VanSaun

Published in: bioRxiv : the preprint server for biology (2023)

This study highlights a mechanism and emphasizes the efficacy of single CXCR1/2 ligand targeting that could be beneficial to overcoming tumor immune-evasion even in the obese PDAC patient population.

Keyphrases

adipose tissue
metabolic syndrome
type diabetes
weight loss
insulin resistance
cancer therapy
obese patients