Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury.
Zachary A MatthayAlexander T FieldsBrenda Nunez-GarciaJohn J ParkChayse JonesAleksandra LeligdowiczCarolyn M HendricksonRachael A CallcutMichael A MatthayLucy Z KornblithPublished in: Journal of thrombosis and haemostasis : JTH (2022)
These findings suggest sympathoadrenal activation in trauma patients contributes to impaired ex vivo platelet aggregation, which mechanistically may be explained by a functionally exhausted platelet phenotype under prolonged exposure to high plasma catecholamine levels.
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