Phenotyping Pharyngeal Pathophysiology using Polysomnography in Patients with Obstructive Sleep Apnea.

Scott A SandsBradley A EdwardsPhilip I TerrillLuigi Taranto-MontemurroAli AzarbarzinMelania MarquesLauren B HessDavid P WhiteAndrew Wellman

Published in: American journal of respiratory and critical care medicine (2019)

Phenotypes of pharyngeal dysfunction in OSA are evident from spontaneous changes in ventilation and ventilatory drive during sleep, enabling noninvasive phenotyping in the clinic. Our approach may facilitate precision therapeutic interventions for OSA.

Keyphrases

obstructive sleep apnea
positive airway pressure
high throughput
physical activity
sleep apnea
primary care
oxidative stress
sleep quality
respiratory failure
mechanical ventilation
extracorporeal membrane oxygenation