Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice.
Connie M ArthurSeema R PatelAsish SharmaPatricia E ZerraSatheesh ChonatRyan P JajoskyRoss M FasanoRavi PatelAshley BennettXiaoxi ZhouC John LuckeyKrystalyn E HudsonStephanie C EisenbarthCassandra D JosephsonJohn D RobackJeanne Elise HendricksonSean R StowellPublished in: Transfusion (2022)
Clodronate can inhibit anti-HOD and anti-KEL antibody formation following RBC transfusion in preclinical models. These results suggest that clodronate may provide an alternative approach to actively inhibit or prevent the development of alloantibodies following RBC transfusion, although future studies will certainly be needed to fully explore this possibility.