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l-Asparaginase Encapsulation into Asymmetric Permeable Polymersomes.

Cecilia Zorzi BuenoAlexsandra C ApolinárioAroa Duro-CastanoAlessandro PomaAdalberto PessoaCarlota de Oliveira Rangel-YaguiGiuseppe Battaglia
Published in: ACS macro letters (2020)
This work reports, for the encapsulation of l-asparaginase, an anticancer enzyme into hybrid PMPC 25 -PDPA 70 /PEO 16 -PBO 22 asymmetric polymersomes previously developed by our group, with loading capacities with over 800 molecules per vesicle. Enzyme-loaded polymersomes show permeability and capacity to hydrolyze l-asparagine, which is essential to cancer cells. The nanoreactors proposed in this work can be potentially used in further studies to develop novel therapeutic alternatives based on l-asparaginase.
Keyphrases
  • drug delivery
  • solid state
  • endothelial cells
  • cancer therapy
  • electronic health record