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H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns.

Ceren ZorHolly A ReeveJonathan QuinsonLisa A ThompsonThomas H LonsdaleFrank DillonNicole GrobertKylie A Vincent
Published in: Chemical communications (Cambridge, England) (2018)
We describe the implementation of a system of immobilised enzymes for H2-driven NADH recycling coupled to a selective biotransformation to enable H2-driven biocatalysis in flow. This approach represents a platform that can be optimised for a wide range of hydrogenation steps and is shown here for enantioselective ketone reduction and reductive amination.
Keyphrases
  • carbon nanotubes
  • primary care
  • healthcare
  • high throughput
  • mass spectrometry
  • single cell