Circular RNAs: Potential Star Molecules Involved in Diabetic Retinopathy.
Miao HeRouxi ZhouSen LiuWeijing ChengMingguang HePublished in: Current eye research (2020)
Purpose: To summarize the research status on the function and mechanism of circRNAs in regulating the occurrence of diabetic retinopathy (DR). Methods: We systematically searched PubMed, Embase.com, and ARVO Abstracts website and reviewed relevant studies. Results: Thousands of circRNAs were found to be aberrantly expressed in DR patients, animal models, or cell models. A few circRNAs, such as cPWWP2A, circDNMT3B, circHIPK3, circ_0005015, et al were demonstrated to play an important role in DR by regulating the angiogenesis, proliferation, apoptosis, and inflammatory response of various cells in the retina. Conclusion: CircRNAs are involved in the development of DR. CircRNAs can not only serve as DR biomarkers, but also become therapeutic targets for DR. The role of plenty of circRNAs in DR is yet to be discovered.
Keyphrases
- diabetic retinopathy
- editorial comment
- inflammatory response
- optical coherence tomography
- cell cycle arrest
- end stage renal disease
- chronic kidney disease
- ejection fraction
- cell death
- stem cells
- prognostic factors
- endothelial cells
- vascular endothelial growth factor
- patient reported outcomes
- mesenchymal stem cells
- human health