Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells.
Simon MelderisJulia HagensteinMatthias Tobias WarkotschJulien DangGeorg Rudolf HerrnstadtChristoph Benjamin NiehusKatrin NeumannUlf PanzerCarmen BerasainMatias A AvilaPierre-Louis TharauxGisa TiegsOliver M SteinmetzPublished in: Journal of the American Society of Nephrology : JASN (2020)
AREG is a proinflammatory mediator of GN via (1) enhancing renal pathogenic myeloid cell infiltration and (2) direct effects on M/M polarization, proliferation, and cytokine secretion. The AREG/EGFR axis is a potential therapeutic target for acute GN.
Keyphrases
- induced apoptosis
- dendritic cells
- bone marrow
- acute myeloid leukemia
- small cell lung cancer
- liver failure
- cell cycle arrest
- signaling pathway
- single cell
- epidermal growth factor receptor
- cell therapy
- respiratory failure
- endoplasmic reticulum stress
- cell death
- human health
- stem cells
- mesenchymal stem cells
- oxidative stress
- intensive care unit
- extracorporeal membrane oxygenation
- mechanical ventilation