miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis.

L ChenM H Al-MossawiA RidleyT SekineArianne HammitzschJ de WitD SimoneH ShiF PenkavaM Kurowska-StolarskaI PulyakhinaJ C KnightTae Jong KimP Bowness

Published in: Annals of the rheumatic diseases (2016)

AS Th17 cells have a specific miR signature and upregulate miR-10b in vitro. Our data suggest that miR-10b is upregulated by proinflammatory cytokines and may act as a feedback loop to suppress IL-17A by targeting MAP3K7. miR-10b is a potential therapeutic candidate to suppress pathogenic Th17 cell function in patients with AS.

Keyphrases

ankylosing spondylitis
induced apoptosis
rheumatoid arthritis
disease activity
cell proliferation
transcription factor
cell cycle arrest
long non coding rna
electronic health record
long noncoding rna
big data
systemic lupus erythematosus
signaling pathway
machine learning
cell death
pi k akt
high density