Autophagy-mediated occludin degradation contributes to blood-brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models.
Kyeong-A KimDonghyun KimJeong-Hyeon KimYoung-Jun ShinEun-Sun KimMuhammad AkramEun-Hye KimArshad MajidSeung-Hoon BaekOk-Nam BaePublished in: Fluids and barriers of the CNS (2020)
Our findings provide evidence that autophagy plays an important role in ischemia-induced occludin degradation and loss of BBB integrity.
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