Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer.

Isabel HeideggerGeorgios FotakisAnne OffermannJermaine GoveiaSophia DaumStefan SalcherAsma NoureenHetty Timmer-BosschaGeorg SchäferAnnemiek WalenkampSven PernerAleksandar BeatovicMatthieu MoisseChristina PlattnerAnne KrogsdamJohannes HaybaeckSieghart SopperStefanie ThalerMarkus A KellerHelmut KlockerZlatko TrajanoskiDominik WolfAndreas Pircher

Published in: Molecular cancer (2022)

Overall, our comprehensive analysis identified novel PCa TEC targets and highlights CXCR4/CXCL12 interaction as a potential novel target to interfere with tumor angiogenesis in PCa.

Keyphrases

prostate cancer
radical prostatectomy
endothelial cells
cell migration
genome wide
gene expression
dna methylation
risk assessment