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Hypoxic stress accelerates the propagation of pathological alpha-synuclein and degeneration of dopaminergic neurons.

Mengyuan GuoWeijin LiuHanjiang LuoQianqian ShaoYuning LiYakun GuYuying GuanWei MaMin ChenHui YangXun-Ming JiJia Liu
Published in: CNS neuroscience & therapeutics (2022)
Hypoxia was shown to accelerate the pathological progression and damage phenotype in PD model mice. The results provided a promising research target for determining common interventions for PD in the future.
Keyphrases
  • spinal cord
  • oxidative stress
  • physical activity
  • current status
  • high fat diet induced
  • endothelial cells
  • stress induced
  • insulin resistance
  • metabolic syndrome
  • adipose tissue
  • heat stress
  • wild type
  • skeletal muscle