Hypoxic stress accelerates the propagation of pathological alpha-synuclein and degeneration of dopaminergic neurons.
Mengyuan GuoWeijin LiuHanjiang LuoQianqian ShaoYuning LiYakun GuYuying GuanWei MaMin ChenHui YangXun-Ming JiJia LiuPublished in: CNS neuroscience & therapeutics (2022)
Hypoxia was shown to accelerate the pathological progression and damage phenotype in PD model mice. The results provided a promising research target for determining common interventions for PD in the future.