Quantifying Proximal Collecting Tubule Deficiency in Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Fetopathy.

Jessica SaundersAllison Marie Callejas SalgadoJoseph Y TingCherry MammenJefferson Terry Jonathan W Bush

Published in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (2021)

We have quantified the reduction in AA fetopathy PCT density, and demonstrated in utero cessation may recover PCT differentiation. Future studies may benefit from calculating PCT percentage as a potential biomarker to correlate with post-natal renal function and maternal factors including medication type, dosage, duration, and time from medication cessation.

Keyphrases

angiotensin converting enzyme
angiotensin ii
vascular smooth muscle cells
healthcare
south africa
adverse drug
current status
birth weight
pregnancy outcomes
binding protein
smoking cessation