Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication.
Irati Antzin-AnduetzaCharlotte MahietLuke A GrangerCharlotte OdendallChad M SwansonPublished in: Retrovirology (2017)
The HIV-1 RNA sequence contains low abundance of CpG dinucleotides. Increasing the abundance of CpG dinucleotides inhibits multiple steps of the viral life cycle, providing a functional explanation for why CpG dinucleotides are suppressed in HIV-1.